How Safe is Delta-8?
- Cannabis Industry

How Safe is Delta-8?

USP Cannabis Expert Panel Identifies Public Health Issues Associated with Delta-8 THC Products & Offers Recommendations

“The fact of the matter is that little is known about the products labeled as containing delta-8, so much so that the FDA and CDC have both released advisories about the products. In addition, depending on how the products are produced, unknown impurities may be introduced, including minor and synthetic cannabinoid compounds that are not naturally occurring in cannabis,” explains Dr. Ikhlas Khan, Chairman of USP’s Expert Panel on cannabis.

“Products containing delta-8 can be found in gas stations, convenience stores, and are readily available over the internet without any warnings or safeguards, providing consumers with a false sense of security that these products are safe for consumption,” notes David Vaillencourt, CEO of The GMP Collective and ASTM International member. “With many other synthetically derived cannabinoids continuing to emerge in the marketplace, quality-based approaches should be used to address this issue.”

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USP’s commentary, It’s time to hold cannabinoid products to the highest standard: USP Cannabis Panel statement on Delta8-THC looks at a number of issues surrounding the controversies of delta-8 THC and recommends:

  • Clinical research into the investigation of minor cannabinoids, such as delta-8 THC.
  • That products labeled as delta-8 THC should be tested for synthetic impurities, and the levels of impurities should be controlled until they have been demonstrated as safe.
  • The need for systematic clinical investigations supported by quality research materials and methods.
  • Recognition of emerging concerns from novel substances. The use of minor cannabinoids and their compounds should be subjected to systematic preclinical and clinical investigations.

“Synthetically derived cannabinoids are not necessarily inherently unsafe if they are quality controlled and shown to be safe. By using public quality standards, we can help control the quality of the products and set appropriate limits for impurities. USP has been using data-driven approaches to quality standards development for over two hundred years and is well equipped to address this growing health concern in a proactive, scientific process,” said Dr. Nandakumara Sarma, Director of Dietary Supplements and Herbal Medicines for USP.

Representatives from USP and ASTM will present the two technical papers as part of ASTM’s upcoming 2nd Global Workshop on Advancing the Field of Cannabis through Standardization, held virtually on Dec. 14, 2021Click here for more information or to register.

For more information about USP’s work and their cannabis reference standards to protect public health and promote sound research in the cannabis industry, go to

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About USP

USP is an independent, nonprofit, scientific organization that sets quality standards for medicines, dietary supplements, and food ingredients worldwide. USP’s quality standards are enforceable in the United States by the Food and Drug Administration and legally recognized in more than 50 countries. These standards are continuously developed and revised by more than 750 volunteer experts in science, industry, healthcare, and academia, are also used in more than 150 countries. Learn more at

How Safe is Delta-8?

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