Those who have used CBD for a long time know how beneficial this substance can be for the body and mind.
The effects of cannabidiol, unlike THC (another substance derived from cannabis Sativa ), are not psychotropic and guarantee optimal integration to therapies, both in case of minor annoyances and of help in the treatment of certain pathologies. In addition, CBD can also be used for preventive purposes: together with a healthy lifestyle, it helps maintain the balance of our body.
However, those who take CBD (in the form of oil, crystals, or other types of preparation, including food ) must know that it can present interactions with certain drugs and medicines, as well as if some foods are taken at the same time (coffee, for example, or fruits such as mango). So what are these interactions, and with what types of drugs do they occur? Let’s find out together.
It is important to establish the quantities and methods of taking CBD
A premise before starting to explain in detail the mechanism of the interactions between CBD and some drugs.
If CBD is taken in minimal quantities, the side effects are practically nil, and the remedy is safe. The drawbacks arise when you start taking more CBD.
However, it must be said that the standard quantity has not yet been identified by scientific research; therefore, the effects on the organism are completely subjective. Having clarified this, it must be emphasized that it is a question of metabolism.
In practice, the simultaneous intake of CBD could hinder the correct disposal of certain medicines by the excretory organs (liver, kidneys, intestine, spleen), creating side effects or even complications.
It happens, for example, with the whole category of anticoagulant drugs, drugs that aim to thin the blood. In general, even with all so-called “life-saving” drugs. Therefore, if you use these medicines, it is necessary to establish the dosage of CBD (and evaluate the possibility of interrupting its integration) with your doctor.
In addition to the quantity, the intake method also seems to be relevant. For example, if the interactions have been ascertained in the oral intake mode of CBD, there is no evidence instead that an inhalation intake can induce the same side effects.
Side effects of concomitant drug use: a question of metabolism
But how and why do these interactions take place? As we have anticipated, a question of metabolism. To understand this concept well, we need to think about grapefruit.
We know that this citrus fruit has several interactions with certain drugs, and doctors often recommend not to drink grapefruit juice if you are carrying out an antibiotic treatment, etc. However, the principle of cannabis Sativa behaves the same way as grapefruit.
Both can no longer make an enzyme, cytochrome P450, present in the liver and intestine and responsible for detoxifying the body.
Consequence? One becomes intoxicated because drug residues accumulate in the liver and blood. Therefore, if the doctor advises against eating grapefruit during treatment with certain medicines, the supplementation with CBD must also be automatically eliminated.
Which drugs or substances interact with cannabidiol
And here we are: what are the categories of drugs that interact with the cannabinoid CBD?
We have already mentioned anticoagulants.
To the latter, we must add all those metabolized by cytochrome P450.
Anesthetics, antiepileptic, and beta-blockers are among them, but also commonly used drugs, such as proton pump inhibitors (antacids against reflux) or NSAIDs. These anti-inflammatories are also used against a simple headache.
Be careful with antihistamines, against allergies, antidiabetics, antivirals, and hypoglycemic agents—finally, a great deal of caution with hypnotics, sleeping pills, and tranquilizers.
CBD and psychiatric drugs: how to behave in these cases? Research shows that cannabidiol is an aid in the treatment of anxiety and depression disorders. But if you are already on psychiatric drugs and want to combine the treatment with a CBD-based product, you must consult your doctor. In this context, research is still ongoing, and the simultaneous intake of products whose interaction is not known is not recommended precisely to avoid the comparison of side effects. Therefore, if you want to buy a CBD product but are on psychiatric drugs, ask your doctor or a doctor experienced in cannabinoid therapies for advice.
But does CBD always interact negatively with drugs? Absolutely not! There are many cases in which cannabidiol positively interferes with other categories of medicines, of which it can even reduce certain side effects.
The recommendation always remains to seek the advice of the attending physician and never rely on do-it-yourself, an attitude that could prove dangerous.
CBD and drugs: are there interactions? When not to take them together
This article is not, nor is it intended to be, a substitute for professional medical advice, diagnosis, or treatment and should never be relied upon for specific medical advice. The views expressed in this article are the expert’s views and do not necessarily represent the views of CannaList BIZ.